Hassler, Matthew R : rechercher sur Z-Library

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1

RNAi modulation of placental sFLT1 for the treatment of preeclampsia

Turanov, Anton A, Lo, Agnes, Hassler, Matthew R, Makris, Angela, Ashar-Patel, Ami, Alterman, Julia F, Coles, Andrew H, Haraszti, Reka A, Roux, Loic, Godinho, Bruno M D C, Echeverria, Dimas, Pears, Suz

Journal:

Nature Biotechnology

Année:

2018

Langue:

english

Fichier:

PDF, 3.49 MB

english, 2018

2

RNA synthesis via dimer and trimer phosphoramidite block coupling

Matthew Hassler, Yi Qiao Wu, N. Mallikarjuna Reddy, Tak Hang Chan, Masad J. Damha

Journal:

Tetrahedron Letters

Année:

2011

Langue:

english

Fichier:

PDF, 634 KB

english, 2011

3

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

Alterman, Julia F, Hall, Lauren M, Coles, Andrew H, Hassler, Matthew R, Didiot, Marie-Cecile, Chase, Kathryn, Abraham, Jasmin, Sottosanti, Emily, Johnson, Emily, Sapp, Ellen, Osborn, Maire F, Difiglia

Journal:

Molecular Therapy — Nucleic Acids

Année:

2015

Langue:

english

Fichier:

PDF, 2.64 MB

english, 2015

4

Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo

Sharma, Vivek Kumar, Osborn, Maire F., Hassler, Matthew, Echeverria, Dimas, Ly, Socheata, Ulashchik, Egor, Martynenko-Makaev, Yury, Shmanai, Vadim V, Zatsepin, Timofei S., Khvorova, Anastasia, Watts,

Journal:

Bioconjugate Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 953 KB

english, 2018

5

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

Alterman, Julia F., Godinho, Bruno M. D. C., Hassler, Matthew R., Ferguson, Chantal M., Echeverria, Dimas, Sapp, Ellen, Haraszti, Reka A., Coles, Andrew H., Conroy, Faith, Miller, Rachael, Roux, Loic,

Journal:

Nature Biotechnology

Année:

2019

Langue:

english

Fichier:

PDF, 3.18 MB

english, 2019

6

Discovery of 2-substituted benzoxazole carboxamides as 5-HT3 receptor antagonists

Zhicai Yang, David J. Fairfax, Jun-Ho Maeng, Liaqat Masih, Alexander Usyatinsky, Carla Hassler, Soshanna Isaacson, Kevin Fitzpatrick, Russell J. DeOrazio, Jianqing Chen, James P. Harding, Matthew Ishe

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 391 KB

english, 2010

7

Cardiovascular safety evaluations assessment in exercise stress and heart failure models

Craig R. Hassler, Matthew Coffee, Michael Hawk, Michael Stonerook, Matthew Ellinger, Thomas Vinci, Brandon Wood, Robert Lordo, Robert Hamlin

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2008

Langue:

english

Fichier:

PDF, 54 KB

english, 2008

8

Analysis of ECG waveforms collected from telemetered guinea pigs

Eric Benson, Brian Roche, Tom Vinci, Matthew Ellinger, Jeremy Smith, Brandon Wood, Alecia Peppers, Jessica Wise, Craig Hassler

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

9

Effects of ambient temperature upon cardiovascular parameters in primates

Brian M. Roche, Tom Vinci, Jeremy Smith, Eric Benson, Brandon Borders, Matthew Ellinger, Craig Hassler, Brandon Wood, Kevin Hicks

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2010

Langue:

english

Fichier:

PDF, 55 KB

english, 2010

10

Coarse-grained terrigenous sediment deposition on continental rise drifts: A record of Plio-Pleistocene glaciation on the Antarctic Peninsula

Ellen A. Cowan, Claus-Dieter Hillenbrand, Lauren E. Hassler, Matthew T. Ake

Journal:

Palaeogeography, Palaeoclimatology, Palaeoecology

Année:

2008

Langue:

english

Fichier:

PDF, 1.61 MB

english, 2008

11

Design and Synthesis of 4-Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors

Liu, Shuang, Zha, Congxiang, Nacro, Kassoum, Hu, Min, Cui, Wenge, Yang, Yuh-Lin, Bhatt, Ulhas, Sambandam, Aruna, Isherwood, Matthew, Yet, Larry, Herr, Michael T., Ebeltoft, Sarah, Hassler, Carla, Flem

Journal:

ACS Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 858 KB

english, 2014

12

Enantioselective Synthesis of Benzyl (1 S ,2 R ,4 R )-4-( tert -Butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate Using an Iodolactamization As the Key Step

Campbell, Carlton L., Hassler, Carla, Ko, Soo S., Voss, Matthew E., Guaciaro, Michael A., Carter, Percy H., Cherney, Robert J.

Journal:

Journal of Organic Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 758 KB

english, 2009

13

Taking charge of siRNA delivery

Khvorova, Anastasia, Osborn, Maire F, Hassler, Matthew R

Journal:

Nature Biotechnology

Année:

2014

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2014

14

The Branched-Chain Aminotransferase Proteins: Novel Redox Chaperones for Protein Disulfide Isomerase–Implications in Alzheimer's Disease

El Hindy, Maya, Hezwani, Mohammed, Corry, David, Hull, Jonathon, El Amraoui, Farah, Harris, Matthew, Lee, Christopher, Forshaw, Thomas, Wilson, Andrew, Mansbridge, Abbe, Hassler, Martin, Patel, Vinood

Journal:

Antioxidants & Redox Signaling

Année:

2014

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2014

15

Oligonucleotide Synthesis Using Ionic Liquids as Soluble Supports

Donga, Robert A., Hassler, Matthew, Chan, Tak-Hang, Damha, Masad J.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Année:

2007

Langue:

english

Fichier:

PDF, 98 KB

english, 2007

16

Corrigendum: Taking charge of siRNA delivery

Khvorova, Anastasia, Osborn, Maire F, Hassler, Matthew R

Journal:

Nature Biotechnology

Année:

2015

Langue:

english

Fichier:

PDF, 96 KB

english, 2015

17

An orthogonal photolabile linker for the complete “on-support” synthesis/fast deprotection/hybridization of RNA

Lietard, Jory, Hassler, Matthew R., Fakhoury, Johans, Damha, Masad J.

Journal:

Chemical Communications

Année:

2014

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2014

18

Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

Osborn, Maire F., Alterman, Julia F., Nikan, Mehran, Cao, Hong, Didiot, Marie C., Hassler, Matthew R., Coles, Andrew H., Khvorova, Anastasia

Journal:

Nucleic Acids Research

Année:

2015

Langue:

english

Fichier:

PDF, 2.91 MB

english, 2015

19

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Godinho, Bruno MDC, Hall, Lauren M, Haraszti, Reka A, Hassler, Matthew R, Echeverria, Dimas, Aronin, Neil, Khvorova, Anastasia

Journal:

Molecular Therapy — Nucleic Acids

Année:

2016

Langue:

english

Fichier:

PDF, 3.12 MB

english, 2016

20

Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay

Godinho, Bruno M.D.C., Gilbert, James W., Haraszti, Reka A., Coles, Andrew H., Biscans, Annabelle, Roux, Loic, Nikan, Mehran, Echeverria, Dimas, Hassler, Matthew, Khvorova, Anastasia

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Année:

2017

Langue:

english

Fichier:

PDF, 644 KB

english, 2017

21

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Dav

Journal:

Nucleic Acids Research

Année:

2018

Langue:

english

Fichier:

PDF, 7.50 MB

english, 2018

22

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles

Haraszti, Reka Agnes, Miller, Rachael, Didiot, Marie-Cecile, Biscans, Annabelle, Alterman, Julia F., Hassler, Matthew R., Roux, Loic, Echeverria, Dimas, Sapp, Ellen, DiFiglia, Marian, Aronin, Neil, Kh

Journal:

Molecular Therapy

Année:

2018

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2018

23

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing

Mir, Aamir, Alterman, Julia F., Hassler, Matthew R., Debacker, Alexandre J., Hudgens, Edward, Echeverria, Dimas, Brodsky, Michael H., Khvorova, Anastasia, Watts, Jonathan K., Sontheimer, Erik J.

Journal:

Nature Communications

Année:

2018

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2018

24

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

Biscans, Annabelle, Coles, Andrew, Haraszti, Reka, Echeverria, Dimas, Hassler, Matthew, Osborn, Maire, Khvorova, Anastasia

Journal:

Nucleic Acids Research

Année:

2018

Langue:

english

Fichier:

PDF, 12.99 MB

english, 2018

25

TARGETING APOLIPOPROTEIN E WITH TISSUE SPECIFIC SMALL INTERFERING RNAS

Ferguson, Chantal, Grigorenko, Anastasia, Alterman, Julia, Hassler, Matthew, Coles, Andrew, Echeverria, Dimas, Rogaev, Evgeny, Khvorova, Anastasia

Journal:

Alzheimer's & Dementia

Année:

2019

Langue:

english

Fichier:

PDF, 617 KB

english, 2019

26

2â²-O-Methyl at 20-mer Guide Strand 3â² Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

Davis, Sarah M., Sousa, Jacquelyn, Vangjeli, Lorenc, Hassler, Matthew R., Echeverria, Dimas, Knox, Emily, Turanov, Anton A., Alterman, Julia F., Khvorova, Anastasia

Journal:

Molecular Therapy — Nucleic Acids

Année:

2020

Fichier:

PDF, 2.40 MB

2020

27

Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

Ferguson, Chantal M., Echeverria, Dimas, Hassler, Matthew, Ly, Socheata, Khvorova, Anastasia

Journal:

Molecular Therapy — Nucleic Acids

Année:

2020

Fichier:

PDF, 1.29 MB

2020